From Santuario Grande, take I‑25 North toward Santa Fe, a scenic drive of about 59 miles. Exit onto Cerrillos Road and follow it into the heart of Santa Fe’s art district. Meow Wolf’s House of Eternal Return is located at 1352 Rufina Circle, just a few minutes off Cerrillos. Allow around an hour for the trip, and plan extra time for parking, as the venue is a popular attraction.