After exiting the airport, follow signs to I-25 North toward Santa Fe. Stay on I-25 for approximately 10 miles, then take Exit 234 for Tramway Rd. Turn left onto 4th Street NW and continue north through the village of Los Ranchos. Santuario Grande is just a few minutes ahead, nestled in a quiet, scenic neighborhood. Total drive time is about 20–25 minutes, depending on traffic.